The active capsaicin receptor TRPV1

But what is TRPV1 while on the cells of the intestinal epithelium? Its action is linked to that of the EGF ( epidermal growth factor ) , an important receptor in the intestinal proliferation. Here, the researchers used a mouse model that made ​​a lot of neoplasia bowel. TRPV1 their deficiency increased the formation of adenomas , which allows the main author of the article Petrus de Jong, to assert that "the epithelial TRPV1 molecule normally functions as a tumor suppressor in the gut" . For researchers, the signal would control TRPV1 receptor growth factors , such as the EGF receptor.

Mice that are many intestinal tumors survive longer with capsaicin (red) than without (blue). However, if they do not express TRPV1 (black), they survive even worse. © de Jong et al, Journal of Clinical Investigation .

http://androidstars.newsvine.com/_news/2014/08/05/25184635-compatible-anatomical-details-with-trisomy-21
http://androidgeek.ucoz.com/blog/video_a_heck_of_a_sea_a_rare_stripe_seen_at_monaco/2014-08-06-15
http://carmiell.blogspot.com/2014/08/ebola-for-who-epidemic-can-be-controlled.html

The active capsaicin receptor TRPV1

These studies also suggest that capsaicin , a molecule present in peppers, irritating animals could suppress intestinal tumors. This causes a burning sensation when in contact with tissue. Biochemical point of view, this is actually a agonist of TRPV1: it would bind to the receptor and activate as if it were its ligand usual.